Ad ID: 5104
Added: May 15, 2019
Ragweed compounds could protect nerve cells from Alzheimer
As spring arrives in the northern hemisphere, many people are cursing ragweed, a primary culprit in seasonal allergies. But scientists might have discovered a promising new use for some substances produced by the pesky weed. In ACS’ Journal of Natural Products, researchers have identified and characterized ragweed compounds that could help nerve cells survive in the presence of Alzheimer’s disease (AD) peptides.
Those with AD, a neurodegenerative disorder, often have impaired judgment, cognition, memory and behavior. Scientists have linked AD to the accumulation of amyloid-β (Aβ) peptides in the brain, which form plaques that kill nerve cells. Unfortunately, the five drugs currently approved for AD treatment only delay disease progression for a short time. When Won Keun Oh and colleagues screened 300 natural plant extracts for activity against AD in a preliminary study, they found a surprising candidate: Ambrosia artemisiifolia (common ragweed). This invasive weed, native to North America, has now spread to South America, Asia and much of Europe. Oh and colleagues decided to isolate and characterize the structures of ragweed compounds responsible for this neuroprotective activity.
The researchers isolated 14 compounds from whole ragweed plants that appeared to protect neurons from Aβ-induced toxicity. They determined the structures of the compounds with nuclear magnetic resonance, mass spectrometry and other analytical techniques. Seven of the chemicals, including terpenoids and spermidine conjugates, had been described previously, but the remainder were newly identified terpenoids. When the researchers added the two most active new compounds to a lab dish that contained neurons producing Aβ, about 20 percent more cells survived than without treatment.
The purpose of our website is only to help students to assist, guide and aware them regarding material available. Moreover, it is necessary for you to take the permission if you want to reproduce or commercial purpose.
*All the rights reserved by Developer and Translator.
Help Us Improve This Article
Did you find an inaccuracy? We work hard to provide accurate and scientifically reliable information. If you have found an error of any kind, please let us know.
Add comment. we appropriate your effort.
Share with Us
If you have any scale or any material related to psychology kindly share with us on email@example.com. We help others on behalf of you.